The Canadian Hub for Health Intelligence and Innovation in Infectious Diseases (HI3) is a University of Toronto-led coalition of over 80 partners that brings globally-recognized scientific research, cross-disciplinary talent pipeline, collaborative IP co-creation and talent training, vibrant translational ecosystem supporting commercialization, rich patient cohorts and patient samples, clinical trial recruitment and participation, and health monitoring and intelligence.
HI3 leverages its partners’ strengths, existing assets, and contributions to collaboratively address existing challenges in biologic translation and commercialization through its objectives that will be realized through the three Research Themes in Precision Intervention, Process Innovation, and Health Intelligence with cross-cutting capacities in established and coordinated pathogen surveillance networks; preclinical models and clinical trial execution; and predictive modelling.
Vision
Robust surveillance to isolate and characterize pathogens of concern
Identify susceptible at-risk individuals and create precision interventions
Validate interventions in preclinical models
Translate interventions using next-generation biomanufacturing
Technology transfer interventions and their biomanufacturing blueprint to domestic CDMOs and companies for scale up
Initiate equitable clinical trials in established cohorts
Roll out interventions, prioritizing high-risk individuals and communities and effectively communicate and engage to improve uptake
Mission
Create, translate and manufacture vaccines and therapeutics to meet diverse needs of Canadians.
HI3 mandate is to address challenges that impede timely translation and commercialization of vaccines, biologics and diagnostics as well as development of the industry-ready workforce to fill current and future biomanufacturing jobs:
Challenges in biologic translation & commercialization
Slow or insufficient capacity to scale biomanufacturing
Lack of highly qualified personnel (HQP) with transferable bioindustry skills
Gaps in data sharing between academics and industry
Lack of coordination of resources that enable rapid pre-clinical and clinical testing
Disconnected pathogen surveillance networks
Objectives
Objectives
Core capacity
Manage cohesive multisectoral interconnected research program that feeds technology development into biomanufacturing sector
Robust data-sharing platform to integrate with other hubs to share knowledge and accelerate technology translation/implementation
Coordination and standardization of measures of vaccine immunogenicity across hubs to develop the right vaccine quickly
Support talent training
Immersive & cross-disciplinary training opportunities including internships.
Establish specialized infrastructure for talent training and industry 4.0 innovation co-developed with industry
Establish inter-hub cooperation and coordination
Robust data-sharing platform to integrate with other hubs to share knowledge and accelerate technology translation/implementation
Coordination and standardization of measures of vaccine immunogenicity across hubs to develop the right vaccine quickly
